Thoughts

能打的来了！莫德纳mRNA疫苗为什么是人类之光？终结新冠病毒，就靠它！

No Comments

重要新闻

  • 11月9日，辉瑞与合作伙伴BioNTech联合宣布：根据3期临床研究的外部独立数据监测委员会（DMC）于2020年11月8日进行的第一次中期疗效分析，在没有新型冠状病毒（SARS-CoV-2）感染证据的受试者中，其基于mRNA的新冠疫苗BNT162b2证明了预防新型冠状病毒肺炎（COVID-19）的有效性：有效率超过90%。这一数据远高于美国FDA要求的50%以上即可获批上市。双方计划在达到所需的安全里程碑后，尽快向美国FDA提交紧急使用授权（EUA）申请。
  • 美国生物科技企业莫德纳（Moderna）11月16日宣布，由该公司研发的新冠肺炎三期试验疫苗mRNA-1273有效性为94.5%。计划在未来几周内向美国申请新冠疫苗的紧急使用权，同时也向其他全球监管机构提交新冠疫苗以获得授权;
  • mRNA疫苗无成功先例，今后灭活疫苗有可能会被完全淘汰，mRNA疫苗生产太方便了

背景知识: 灭活等疫苗VS mRNA疫苗

  • 灭活疫苗，这是最传统的疫苗，包括减毒疫苗、灭活疫苗和裂解疫苗。

    • 所谓的减毒疫苗就是把病原体打残了再用；
    • 所谓的灭活疫苗就是把病原体打死了再用；
    • 所谓的裂解疫苗就是把病原体碎尸万段后再用。
    • 虽然经过了各种特殊的灭活处理，导致其致病性下降或丧失，但仍保持了病毒全部或部分免疫原性，接种后病毒抗原可以刺激机体产生免疫应答，达到保护作用。
    • 这种类型的疫苗，工艺制作较为简单，是传统的疫苗制备方式。但是由于对新冠病毒的致病机理和免疫学机制的研究尚不深入，所以灭活后的疫苗仍然可能携带有害成分；而且目前活病毒培养要求在P3级生物安全条件下进行，产能会受到限制。

  • 核酸疫苗，包括DNA疫苗和mRNA疫苗。

    • DNA疫苗:把病原体的蛋蛋直接活生生打入人体。灭活疫苗可以说是最[笨]的方法，但也可以说是作为兜底的策略，灭活疫苗的缺点是接种次数较多（通常需要2~3剂），但灭活疫苗的技术是最成熟的，这也是我看好国药灭活疫苗的原因。

    • mRNA疫苗:把病原体的小蝌蚪原细胞活生生打入人体。mRNA(信使RNA)就像一个携带着细胞用来合成不同蛋白质的模板。在人类细胞内，根据DNA内的遗传信息制造蛋白质需要两个主要步骤。首先，在细胞核中，DNA编码的信息转录到mRNA上。mRNA从细胞核移动至细胞质，核糖体将其翻译成蛋白质，从而发挥对细胞和组织的功能。与传统疫苗直接引入抗原蛋白刺激宿主免疫应答不同，mRNA疫苗引入编码疾病特异性抗原的mRNA，利用宿主细胞的蛋白质合成机制产生抗原，从而触发免疫应答。在体内，这些外来抗原的产生为免疫系统识别和记忆这种病毒抗原做好了准备，可以抵御未来由相同抗原引起的病毒感染。

    • mRNA疫苗最大的优点就是可以快速制备，安全性较好。这种疫苗的主要缺点，是在运输递送过程中容易出现降解而失效，所以防止降解是关键。

Continue Reading

Reading

Weekly Reading Summary: Aug. 16-Aug. 23, 2020

No Comments

 

The Economist [Fri, 07 Aug 2020]
Many students buy the university experience not just to boost their earning capacity, but also to get away from their parents, make friends and find partners.

In Australia foreign students provide a quarter of universities’ income. In Canada the tuition fees for a science degree at McGill, one of the country’s top universities, cost C$45,656 ($34,000) a year for an overseas student, compared with C$2,623 for a local.

The Economist [Fri, 14 Aug 2020]
Mr Xi’s new economic agenda is to make markets and innovation work better within tightly defined boundaries and subject to all-seeing Communist Party surveillance. It isn’t Milton Friedman, but this ruthless mix of autocracy, technology and dynamism could propel growth for years.

LAST YEAR Zotye, a carmaker, used it to tackle weak sales, and Wuliangye, a distiller, to improve the quality of its baiju; it helped Zheshang Bank to digitise its operations and catalysed the development of energy-saving technologies at China National Nuclear Power. “Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era” is, on the basis of these companies’ annual reports, quite the business-practice panacea.

世界变得越来越复杂，人们意识不到自己有多么无知。结果是，一群对气象学或生物学一窍不通的人就气候变化和转基因作物等议题吵翻了天，而另一群根本不知道伊拉克或乌克兰在哪儿的人，极力主张要对这些地区采取行动。人们很少发觉自己的无知，因为他们会沉浸在一个高度同质性的环境中，其信念被不断自证与加强，鲜有相左之声。 — 尤瓦尔·赫拉利（《人类简史》作者）

曾看到一句很经典的话：当年，懂毛的去了台湾，懂老蒋的留在大陆，两个都懂的去了美国。

他只是辍学，并没有停止学习。

在人类学家玛格丽特·米德的论述里，人类文明最初的标志是“愈合的骨折股骨化石”——在远古时代，断了股骨的人，除非得到他人帮助，否则必死无疑，因为伤者不能打猎，也难逃野兽伤害。

Continue Reading

Thoughts

Fight against the UNQUALIFIED PPEs

No Comments

I am a Chinese!

To Chinese: it is not ashamed to admit problems, it is shameful to hide and do the wrong thing.
To non-Chinese: Chinese are also human beings, there are good people and bad people, same as in your country.

It is a hard year for apparel business (my main business, worked in this field for 20 years, up to now), to keep business running, I have been supplying PPEs to my clients and therefore, have connections with various PPE suppliers.

To learn more about the PPEs, I have joined different wechat groups. Below is a screenshot from one group, the price is surely very very low:

The non-Chinese would say: Chinese are horrible! But, wait! Ask yourself a question: why the unqualified masks can sell? Who bought such masks? The Chinese bad businessman surely should be condemned and punished, the buyers should be the same.

I have read news on bad quality PPEs from China, there are complaints and claims from various countries, Canada even asked Chinese suppliers for recall. Unfortunately, no reports on punishment of importers read.

To fight against the unqualified PPEs, Chinese should have basic business ethics, buyers should focus on quality, rather than price only. Please believe that Chinese factories can always meet your target price, the quality will be surely a problem-if price is unreasonable, I also believe buyers know the fact.

PPEs are about life, Human Lives Matter!

Continue Reading

Work

Summary On Visit of An Medical Protective Supplies Exhibition

No Comments

The Economist [Fri, 03 Jul 2020]
Covid-19 is here for a while at least. The vulnerable will be afraid to go out and innovation will slow, creating a 90% economy that consistently fails to reach its potential. Many people will fall ill and some of them will die. You may have lost interest in the pandemic. It has not lost interest in you.

It is a hard year for everyone, at least 2020. We have seen many historic events-the rampant of Coronavirus, the death of Kobe, the US stock market circuit breaker, the date change of Olympics, the lock-down of many countries, the recession of economy,  the collapse of oil prices…, whatsoever, life need to go on.

BE ALIVE is the number 1 priority, especially for the elders and vulnerables. Herd immunity? Or strict control regardless of privacy like China? I am not sure which one is right.

It has been about 5 months since my last business trip, for security. My company mainly deal with the apparel business, however, we also deal with PPEs due to impact of the virus.

Attended a medical supplies exhibition, seems business in China is recovering. And glad to meet many good factories during the exhibition, so we can continue supply PPEs to our clients with better products.

Safety is important, China government is trying to control the spread of covid-19, airport security is wearing protective gowns, and sit on each other seat is advised:
 

Also, Chinese can generally follow the rules, everyone at the exhibition wears face mask:

Click Continue Reading to read the full content

Continue Reading

Work

Want 3M 1860 Masks? Be careful, you might dealing with scammers!

No Comments

I run a company in China, specialized in apparel OEM and apparel stocklots business. However:
1) At the beginning of this year, China factories can not run;
2) Then later, buyers cancel orders and no new orders come in.
Therefore, we are forced to supply PPEs. Many Chinese clothes factories change to produce masks, so we can source from them easily. We firstly supply masks, and then supply other products, including Hand Sanitizers and Bottles, Protective Clothes/Gowns, Protective Gloves, Protective Medical Goggles (high quality goggles, can also use as ski goggles), Hospital Beds,Isolation Chamber, Sanitary Wipe, Infrared Thermometer, Disinfection Tunnel, Non Woven Fabric For Mask.

3M standards for good quality, and many buyers want to source 3M masks from China. We are able to supply 3M 9001/9002/9501/9502, but can NOT supply 3M 1860.

Recently one of our client contacted us for 3M 1860, and the order is real. We had an investigation on the supply chain. I am fully responsible for the information provide below:

  •  All 3M medical masks are under Chinese Government control, including 1860, 3M only supply to China Government, this is directly from my connection in 3M China.
  •  There are many brokers in China, saying that they have connections with 3M management officials, or with connections with big China State companies, so they can get the products. All are scammers!
  •  I talked with one broker, to know how they run the business, and was told 1 billion pcs can be ready within 7 days, sign contract with 3M and 3M will prepare the products from various warehouses all around the world. This could be ridiculous!
  •  I also checked with my friend who work at China Customs, they have data on how many exports of 3M, the information is very very few 1860 shipped out of China;
  • I was also told by the 3M China connection that there is no inventory at all. Not to mention 1 billion, even if 1 million pcs, delivery time is next year, if we place order now.

However, seems the broker is really working hard, he provided me the “Customs Declaration Form of Imported Goods” document, which should be issued by the China Customs and shows they have helped one Chinese company imported 50 million pcs 3M 1860 into China, as below, seems it is authentic, but there is one problem. If you can not find the tell-tale, contact me, I will advise.

Continue Reading

Work

Masks Story in China, and the supply Chain

No Comments

Bad Indian mask producer

Bad Chinese mask producer

This could be kidding, NO good quality mask would print so much info. 

In a world of Chaos, Everyone need to be good, and wise.

Ever since the outbreak of Coronavirus in China, my company has started dealing with with PPEs, this post is not aimed to sell, but to share, on what you need to know.

In Feb. and Mar., the situation in China is: disposable mask price goes from USD0.50/pack (20pcs) to USD10.00/pack (the highest level in my city), but nowhere to buy, because lack of supply. 

The Superpower Mighty Chinese Government immediately released policies to encourage factories (mainly clothes factories, car factories) to establish production lines, supply increased, adding that Chinese follow the lockdown policy, mask shortage eased.

Chinese government have no strict quality control on masks at that time. Poor Chinese!

Till end of Feb., SMS fabric (core fabric for mask) goes from USD3,000/MT to USD30,000/MT. Now? USD90,000/MT!

At the same time, huge demand from overseas countries stimulates the supply. Horrible business people produce in horrible workshop (see pics left), quality is a big problem.

Continue Reading